Ipamorelin is a synthetic pentapeptide that selectively activates the ghrelin/growth hormone secretagogue receptor pathway, stimulating growth hormone release from the pituitary gland. By mimicking ghrelin ipamorelin binds to the GHSR-1a receptor, influencing various anabolic processes, including appetite regulation and energy metabolism. Studies have shown its possibility to improve gastrointestinal motility particularly in postoperative ileus. Ipamorelin helps increase weight without leading to organ enlargement, in men and shows potential as an approach, for addressing body composition concerns.
Sinha, D.K., Balasubramanian, A., Tatem, A.J., Rivera-Mirabal, J., Yu, J., Kovac, J., Pastuszak, A.W. and Lipshultz, L.I., 2020. Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Translational Andrology and Urology.
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Sinha, D.K., Balasubramanian, A., Tatem, A.J., Rivera-Mirabal, J., Yu, J., Kovac, J., Pastuszak, A.W. and Lipshultz, L.I., 2020. Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Translational Andrology and Urology.
Sinha, D.K., Balasubramanian, A., Tatem, A.J., Rivera-Mirabal, J., Yu, J., Kovac, J., Pastuszak, A.W. and Lipshultz, L.I., 2020. Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Translational Andrology and Urology.
Sinha, D.K., Balasubramanian, A., Tatem, A.J., Rivera-Mirabal, J., Yu, J., Kovac, J., Pastuszak, A.W. and Lipshultz, L.I., 2020. Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Translational Andrology and Urology.
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