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Dehydroepiandrosterone (DHEA)

Dehydroepiandrosterone (DHEA)

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DHEA 100
Euro-Pharmacies
Substance Overview and History

Dehydroepiandrosterone (DHEA) is a steroid hormone produced in the adrenal glands, gonads, and brain, serving as a precursor to androgens and estrogens like testosterone and estradiol. Its levels peak in early adulthood and decline with age, often associated with reduced energy and hormonal imbalances. In reproductive medicine, DHEA is used to support fertility, particularly for women with diminished ovarian reserve (DOR) or premature ovarian insufficiency (POI). By improving oocyte quality and enhancing ovarian response during controlled ovarian hyperstimulation (COH), DHEA contributes to better outcomes in assisted reproductive technology (ART). Additionally, it influences pathways critical for follicular development, including apoptosis and oxidative stress regulation.

References:

Cakir, C., Kuspinar, G., Aslan, K., Bozyigit, C., Kasapoglu, I., Dirican, M., Uncu, G., & Avci, B. (2024) Dehydroepiandrosterone modulates the PTEN/PI3K/AKT signaling pathway to alleviate 4-vinylcyclohexene diepoxide-induced premature ovarian insufficiency in rats, Experimental Animals. 

Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.

For more details consult with your doctor or healthcare professional.

FAQ
What is DHEA?
DHEA is a naturally occurring steroid hormone produced in the adrenal glands, gonads, and brain, serving as a precursor to androgens and estrogens.
References:

Cakir, C., Kuspinar, G., Aslan, K., Bozyigit, C., Kasapoglu, I., Dirican, M., Uncu, G., & Avci, B. (2024) Dehydroepiandrosterone modulates the PTEN/PI3K/AKT signaling pathway to alleviate 4-vinylcyclohexene diepoxide-induced premature ovarian insufficiency in rats, Experimental Animals. 

What is the primary function of DHEA?
DHEA helps regulate hormone balance by converting into sex hormones like testosterone and estradiol, supporting various physiological processes.
References:

Cakir, C., Kuspinar, G., Aslan, K., Bozyigit, C., Kasapoglu, I., Dirican, M., Uncu, G., & Avci, B. (2024) Dehydroepiandrosterone modulates the PTEN/PI3K/AKT signaling pathway to alleviate 4-vinylcyclohexene diepoxide-induced premature ovarian insufficiency in rats, Experimental Animals. 

How does DHEA change with age?
DHEA levels peak in early adulthood and decline significantly with age, often associated with reduced energy, hormonal imbalances, and aging-related changes.
References:

Cakir, C., Kuspinar, G., Aslan, K., Bozyigit, C., Kasapoglu, I., Dirican, M., Uncu, G., & Avci, B. (2024) Dehydroepiandrosterone modulates the PTEN/PI3K/AKT signaling pathway to alleviate 4-vinylcyclohexene diepoxide-induced premature ovarian insufficiency in rats, Experimental Animals.