DHEA, a naturally occurring steroid hormone, plays a vital role as a precursor to key androgens and estrogens. Synthesized primarily in the adrenal glands, it supports hormonal balance and overall vitality, with levels declining significantly as individuals age. In fertility treatments, DHEA is often integrated into assisted reproductive technology (ART) protocols to enhance outcomes for women with diminished ovarian reserve (DOR) or premature ovarian insufficiency (POI). It improves ovarian response, oocyte quality, and embryo development. DHEA is also recognized for its broader cellular effects, modulating oxidative stress and apoptosis pathways that are essential for follicular growth. Its therapeutic use continues to expand across diverse medical fields.
Cakir, C., Kuspinar, G., Aslan, K., Bozyigit, C., Kasapoglu, I., Dirican, M., Uncu, G., & Avci, B. (2024) Dehydroepiandrosterone modulates the PTEN/PI3K/AKT signaling pathway to alleviate 4-vinylcyclohexene diepoxide-induced premature ovarian insufficiency in rats, Experimental Animals.
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Cakir, C., Kuspinar, G., Aslan, K., Bozyigit, C., Kasapoglu, I., Dirican, M., Uncu, G., & Avci, B. (2024) Dehydroepiandrosterone modulates the PTEN/PI3K/AKT signaling pathway to alleviate 4-vinylcyclohexene diepoxide-induced premature ovarian insufficiency in rats, Experimental Animals.
Cakir, C., Kuspinar, G., Aslan, K., Bozyigit, C., Kasapoglu, I., Dirican, M., Uncu, G., & Avci, B. (2024) Dehydroepiandrosterone modulates the PTEN/PI3K/AKT signaling pathway to alleviate 4-vinylcyclohexene diepoxide-induced premature ovarian insufficiency in rats, Experimental Animals.
Cakir, C., Kuspinar, G., Aslan, K., Bozyigit, C., Kasapoglu, I., Dirican, M., Uncu, G., & Avci, B. (2024) Dehydroepiandrosterone modulates the PTEN/PI3K/AKT signaling pathway to alleviate 4-vinylcyclohexene diepoxide-induced premature ovarian insufficiency in rats, Experimental Animals.