Ipamorelin is a selective growth hormone secretagogue that activates the ghrelin receptor, stimulating GH release without significantly affecting cortisol or prolactin. Unlike traditional GH therapies, it promotes muscle growth and fat accumulation while minimizing risks of organ enlargement. Studies in GH-deficient and GH-intact models show early weight gain and increased fat deposits, especially within the first two weeks. Additionally, ipamorelin has been studied for its potential to enhance gastrointestinal motility, making it useful in postoperative recovery .
Sinha, D.K., Balasubramanian, A., Tatem, A.J., Rivera-Mirabal, J., Yu, J., Kovac, J., Pastuszak, A.W. and Lipshultz, L.I., 2020. Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Translational Andrology and Urology.
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Sinha, D.K., Balasubramanian, A., Tatem, A.J., Rivera-Mirabal, J., Yu, J., Kovac, J., Pastuszak, A.W. and Lipshultz, L.I., 2020. Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Translational Andrology and Urology.
Sinha, D.K., Balasubramanian, A., Tatem, A.J., Rivera-Mirabal, J., Yu, J., Kovac, J., Pastuszak, A.W. and Lipshultz, L.I., 2020. Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Translational Andrology and Urology.
Sinha, D.K., Balasubramanian, A., Tatem, A.J., Rivera-Mirabal, J., Yu, J., Kovac, J., Pastuszak, A.W. and Lipshultz, L.I., 2020. Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Translational Andrology and Urology.