Tirzepatide, marketed as Mounjaro® by Eli Lilly, is a dual GIP/GLP-1 receptor agonist approved by the FDA in 2022 for Type 2 Diabetes (T2D) management. It uniquely targets both glycemic control and weight loss, outperforming traditional GLP-1 receptor agonists. Clinical trials, especially SURPASS-4, demonstrated significant HbA1c and body weight reduction, along with reduced mortality compared to insulin glargine. With a comparable safety profile to GLP-1RAs and similar gastrointestinal side effects, Tirzepatide offers a groundbreaking approach to T2D, with potential applications in obesity and related metabolic conditions.
Gallwitz, B., 2022. Clinical perspectives on the use of the GIP/GLP-1 receptor agonist tirzepatide for the treatment of type-2 diabetes and obesity. Frontiers in Endocrinology.
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Gallwitz, B., 2022. Clinical perspectives on the use of the GIP/GLP-1 receptor agonist tirzepatide for the treatment of type-2 diabetes and obesity. Frontiers in Endocrinology.
Gallwitz, B., 2022. Clinical perspectives on the use of the GIP/GLP-1 receptor agonist tirzepatide for the treatment of type-2 diabetes and obesity. Frontiers in Endocrinology.
Gallwitz, B., 2022. Clinical perspectives on the use of the GIP/GLP-1 receptor agonist tirzepatide for the treatment of type-2 diabetes and obesity. Frontiers in Endocrinology.