Selank’s anxiolytic effects were explored in BALB/C and C57BL/6 mice, showcasing varied responses to stress. In BALB/C mice Selank increased locomotor activity and reduced anxiety, while in C57BL/6 mice, it had no effect. When combined with another drug "naloxone", an opioid antagonist its effectiveness was diminished in BALB/C mice but increased in C57BL/6 mice. Results highlight the role of the enkephalin opioid system in modulating individual responses to Selank, indicating its nuanced mechanism of action across different phenotypes.
Kozlovskiĭ, II., Andreeva, LA., Kozlovskaia, MM., Nadorova, AV., Kolik, LG. (2012). [The role of opioid system in peculiarities of anti-anxiety effect of peptide anxiolytic Selank]. Eksp Klin Farmakol.
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Kozlovskiĭ, II., Andreeva, LA., Kozlovskaia, MM., Nadorova, AV., Kolik, LG. (2012). [The role of opioid system in peculiarities of anti-anxiety effect of peptide anxiolytic Selank]. Eksp Klin Farmakol.
Kozlovskiĭ, II., Andreeva, LA., Kozlovskaia, MM., Nadorova, AV., Kolik, LG. (2012). [The role of opioid system in peculiarities of anti-anxiety effect of peptide anxiolytic Selank]. Eksp Klin Farmakol.
Kozlovskiĭ, II., Andreeva, LA., Kozlovskaia, MM., Nadorova, AV., Kolik, LG. (2012). [The role of opioid system in peculiarities of anti-anxiety effect of peptide anxiolytic Selank]. Eksp Klin Farmakol.
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