Discovered in 2015 through bioinformatics analysis by Lee et al., MOTS-c is a peptide originating from mitochondria. It emerges from a short sequence within human 12S rRNA, comprising 16 amino acids. Unlike typical mitochondrial proteins, MOTS-c is synthesized in the cytoplasm using the universal genetic code, enabling its function in cellular regulation. Studies indicate that its concentration declines in individuals with obesity and that it improves glucose sensitivity while combating weight gain in mice via AMPK pathways so its involvement in alpha and beta cell functions underlines its potential in managing metabolic issues.
Bień, J., Pruszyńska-Oszmałek, E., Kołodziejski, P., Leciejewska, N., Szczepankiewicz, D., & Sassek, M. (2024) 'MOTS-c regulates pancreatic alpha and beta cell functions in vitro', Histochemistry and Cell Biology.
Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.
For detailed information about MOTS-c by Dragon Pharma, consult with your doctor or healthcare professional.
Bień, J., Pruszyńska-Oszmałek, E., Kołodziejski, P., Leciejewska, N., Szczepankiewicz, D., & Sassek, M. (2024) 'MOTS-c regulates pancreatic alpha and beta cell functions in vitro', Histochemistry and Cell Biology.
Bień, J., Pruszyńska-Oszmałek, E., Kołodziejski, P., Leciejewska, N., Szczepankiewicz, D., & Sassek, M. (2024) 'MOTS-c regulates pancreatic alpha and beta cell functions in vitro', Histochemistry and Cell Biology.
Bień, J., Pruszyńska-Oszmałek, E., Kołodziejski, P., Leciejewska, N., Szczepankiewicz, D., & Sassek, M. (2024) 'MOTS-c regulates pancreatic alpha and beta cell functions in vitro', Histochemistry and Cell Biology.
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