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MOTS-c

MOTS-c

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MOTS-c
Dragon Pharma
Substance Overview and History

MOTS-c, discovered by Lee et al. in 2015, is a peptide derived from mitochondria, found through computational research. It originates from a small coding region in human 12S rRNA and is made up of 16 amino acids. Unlike other mitochondrial elements, MOTS-c is produced in the cytoplasm using the standard genetic framework, allowing it to perform various roles in cells and is very important for energy management, improving glucose processing addressing weight gain and regulating pancreatic hormones including insulin and glucagon. Reduced MOTS-c levels have been observed in people with obesity indicating its importance in metabolic balance and its role in protecting against muscle loss and its engagement with the AMPK pathway make it a promising option for treating metabolic issues like diabetes.

References:

Bień, J., Pruszyńska-Oszmałek, E., Kołodziejski, P., Leciejewska, N., Szczepankiewicz, D., & Sassek, M. (2024) 'MOTS-c regulates pancreatic alpha and beta cell functions in vitro', Histochemistry and Cell Biology.

Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.

For more details consult with your doctor or healthcare professional.

FAQ
What is MOTS-c?
MOTS-c is a peptide derived from the mitochondrial 12S rRNA, discovered in 2015.
References:

Bień, J., Pruszyńska-Oszmałek, E., Kołodziejski, P., Leciejewska, N., Szczepankiewicz, D., & Sassek, M. (2024) 'MOTS-c regulates pancreatic alpha and beta cell functions in vitro', Histochemistry and Cell Biology.

What is unique about MOTS-c's genetic translation?
Unlike other mitochondrial peptides, it uses the standard genetic code.
References:

Bień, J., Pruszyńska-Oszmałek, E., Kołodziejski, P., Leciejewska, N., Szczepankiewicz, D., & Sassek, M. (2024) 'MOTS-c regulates pancreatic alpha and beta cell functions in vitro', Histochemistry and Cell Biology.

What makes MOTS-c so crucial for research purposes?
Being an area of research its impact, on metabolism and its potential, in the treatment of metabolic disorders are highly valued.
References:

Bień, J., Pruszyńska-Oszmałek, E., Kołodziejski, P., Leciejewska, N., Szczepankiewicz, D., & Sassek, M. (2024) 'MOTS-c regulates pancreatic alpha and beta cell functions in vitro', Histochemistry and Cell Biology.