Ketotifen 1 - Pharmaceutical Grade

Ketotifen, traditionally used as a mast cell stabilizer and H1 antagonist, has shown emerging potential as an anti-fibrotic agent. Studies reveal its direct effects on fibroblasts, disrupting TGFβ1-driven processes like αSMA expression and cytoskeletal protein synthesis. In murine models of bleomycin-induced skin fibrosis, ketotifen reduced dermal thickness and collagen deposition. Mechanistically, it inhibits YAP/TAZ activity and Akt phosphorylation, suppressing fibrotic signaling. By modulating fibroblast activity and mast cell response, ketotifen presents a novel therapeutic avenue for systemic sclerosis, burn wounds, and chronic fibrosis.

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