Hydrochlorothiazide (HCTZ), a widely prescribed diuretic for hypertension, has been linked to an elevated risk of squamous cell carcinoma (SCC) in kidney transplant recipients undergoing immunosuppressive therapy. A study involving 2,496 transplant patients in France revealed a two-fold increase in SCC risk associated with HCTZ use, attributed to its photosensitizing effects. While no significant link to basal cell carcinoma (BCC) was observed, the study highlights the importance of close monitoring for SCC in transplant recipients prescribed HCTZ, given their heightened vulnerability to skin cancers .
Letellier, T., Leborgne, F., Kerleau, C., Gaultier, A., Dantal, J., & Ville, S., on behalf of the Divat Consortium. (2020) 'Association between Use of Hydrochlorothiazide and Risk of Keratinocyte Cancers in Kidney Transplant Recipients', Clinical Journal of the American Society of Nephrology.
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Letellier, T., Leborgne, F., Kerleau, C., Gaultier, A., Dantal, J., & Ville, S., on behalf of the Divat Consortium. (2020) 'Association between Use of Hydrochlorothiazide and Risk of Keratinocyte Cancers in Kidney Transplant Recipients', Clinical Journal of the American Society of Nephrology.
Letellier, T., Leborgne, F., Kerleau, C., Gaultier, A., Dantal, J., & Ville, S., on behalf of the Divat Consortium. (2020) 'Association between Use of Hydrochlorothiazide and Risk of Keratinocyte Cancers in Kidney Transplant Recipients', Clinical Journal of the American Society of Nephrology.
Letellier, T., Leborgne, F., Kerleau, C., Gaultier, A., Dantal, J., & Ville, S., on behalf of the Divat Consortium. (2020) 'Association between Use of Hydrochlorothiazide and Risk of Keratinocyte Cancers in Kidney Transplant Recipients', Clinical Journal of the American Society of Nephrology.
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