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Hydrochlorothiazide

Hydrochlorothiazide

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Substance Overview and History

Hydrochlorothiazide (HCTZ), a diuretic used to treat hypertension, has been linked to an increased risk of squamous cell carcinoma (SCC) in kidney transplant recipients, who are already at heightened cancer risk due to immunosuppression. A study of 2,496 transplant patients revealed a two-fold increased risk of SCC among those exposed to HCTZ, with no significant association found for basal cell carcinoma (BCC). SCC risk, amplified by HCTZ’s photosensitizing effects, highlights the importance of monitoring transplant recipients for skin cancers and considering alternative treatments.

References:

Letellier, T., Leborgne, F., Kerleau, C., Gaultier, A., Dantal, J., & Ville, S., on behalf of the Divat Consortium. (2020) 'Association between Use of Hydrochlorothiazide and Risk of Keratinocyte Cancers in Kidney Transplant Recipients', Clinical Journal of the American Society of Nephrology.

Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.

For more details consult with your doctor or healthcare professional.

FAQ
What is Hydrochlorothiazide used for?
Hydrochlorothiazide (HCTZ) is a diuretic commonly prescribed to treat hypertension and edema.
References:

Letellier, T., Leborgne, F., Kerleau, C., Gaultier, A., Dantal, J., & Ville, S., on behalf of the Divat Consortium. (2020) 'Association between Use of Hydrochlorothiazide and Risk of Keratinocyte Cancers in Kidney Transplant Recipients', Clinical Journal of the American Society of Nephrology.

How is Hydrochlorothiazide linked to skin cancer?
HCTZ is a photosensitizing drug that amplifies the carcinogenic effects of ultraviolet (UV) radiation, increasing the risk of squamous cell carcinoma (SCC).
References:

Letellier, T., Leborgne, F., Kerleau, C., Gaultier, A., Dantal, J., & Ville, S., on behalf of the Divat Consortium. (2020) 'Association between Use of Hydrochlorothiazide and Risk of Keratinocyte Cancers in Kidney Transplant Recipients', Clinical Journal of the American Society of Nephrology.

Is Hydrochlorothiazide associated with both SCC and BCC?
Studies have found a two-fold increased risk of SCC in kidney transplant recipients exposed to HCTZ, but no significant association with basal cell carcinoma (BCC).
References:

Letellier, T., Leborgne, F., Kerleau, C., Gaultier, A., Dantal, J., & Ville, S., on behalf of the Divat Consortium. (2020) 'Association between Use of Hydrochlorothiazide and Risk of Keratinocyte Cancers in Kidney Transplant Recipients', Clinical Journal of the American Society of Nephrology.