IGF DES (1-3) - Hemi Pharma

IGF-1 DES, also known as des-N-(1-3) IGF-1, is a truncated variant of IGF-1 lacking the first three N-terminal amino acids. This modification reduces its affinity for IGF binding proteins (IGFBPs), allowing increased local bioavailability and enhanced in vitro potency. IGF-1 DES exhibits greater anabolic and hypoglycemic effects, particularly in the CNS. However, in vivo studies in rats showed limited neuroprotection unless high doses were used. These results suggest IGFBP interaction is essential for full neuroprotective activity, despite IGF-1 DES’s heightened receptor activation.

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