MT-II’s discovery has a unique history rooted in tanning research. It was first designed to mimic natural melanocyte-stimulating hormone (α-MSH) effects on skin pigmentation but revealed surprising proerectile properties during early trials. After a volunteer experienced prolonged erection alongside the intended tanning effects, researchers turned their focus to MT-II’s potential as an erectile dysfunction treatment. Studies have since shown that MT-II’s central mechanisms, mainly through MC4R receptors, can enhance spontaneous erections without acting directly on vascular tissues, opening possibilities for alternative therapies targeting the central nervous system.
King, S.H., Mayorov, A.V., Balse-Srinivasan, P., Hruby, V.J., Vanderah, T.W., and Wessells, H. (2007). Melanocortin receptors, melanotropic peptides and penile erection. Current Topics in Medicinal Chemistry.
Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.
For detailed information about Ultima-Melanotan-II by Ultima Pharmaceuticals, consult with your doctor or healthcare professional.
King, S.H., Mayorov, A.V., Balse-Srinivasan, P., Hruby, V.J., Vanderah, T.W., and Wessells, H. (2007). Melanocortin receptors, melanotropic peptides and penile erection. Current Topics in Medicinal Chemistry.
King, S.H., Mayorov, A.V., Balse-Srinivasan, P., Hruby, V.J., Vanderah, T.W., and Wessells, H. (2007). Melanocortin receptors, melanotropic peptides and penile erection. Current Topics in Medicinal Chemistry.
King, S.H., Mayorov, A.V., Balse-Srinivasan, P., Hruby, V.J., Vanderah, T.W., and Wessells, H. (2007). Melanocortin receptors, melanotropic peptides and penile erection. Current Topics in Medicinal Chemistry.
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