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Sildenafil 50
Sildenafil 50 - Androlex

Sildenafil 50 - Androlex

Brand:
Category:
Substance:
Dosage:
50 mg/tab
Package:
20 tablets
Price:
$22.00 - $22.00
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Product Overview

Sildenafil citrate, branded as Viagra, was synthesized in 1989 by Pfizer in the UK during efforts to develop a treatment for angina. By selectively inhibiting PDE5, it enhanced the NO/cGMP pathway, relaxing vascular smooth muscle. Though it underperformed in cardiovascular trials, researchers observed improved erectile function, prompting a shift in focus. Approved in 1998 after extensive trials, Viagra became the first oral ED treatment, earning global recognition for its safety and effectiveness.

References:

Dunzendorfer, U. (2012) Sildenafil. Switzerland: Birkhäuser Basel.

Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.

For detailed information about Sildenafil 50 by Androlex, consult with your doctor or healthcare professional.

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FAQ
What does Sildenafil citrate do at the cellular level?
Sildenafil citrate enhances cGMP levels in smooth muscle cells, which lowers calcium levels and causes vasodilation.
References:

Dunzendorfer, U. (2012) Sildenafil. Switzerland: Birkhäuser Basel.

What role does nitric oxide play in the action of Sildenafil citrate?
Sildenafil citrate works downstream of nitric oxide by preserving cGMP, a key molecule in the NO pathway.
References:

Dunzendorfer, U. (2012) Sildenafil. Switzerland: Birkhäuser Basel.

Is the action of Sildenafil citrate linked to nitrate tolerance?
Sildenafil citrate was developed to avoid the rapid tolerance seen with nitrates by targeting cGMP breakdown instead.
References:

Dunzendorfer, U. (2012) Sildenafil. Switzerland: Birkhäuser Basel.