Known as an antihypertensive agent, telmisartan has recently gained attention for its possible antitumor properties. Studies show that telmisartan effectively slows the proliferation of esophageal squamous cell carcinoma (ESCC) cells by promoting cell-cycle arrest, a vital mechanism in cancer inhibition. By targeting proteins such as cyclin A2 and CDK2, telmisartan arrests cancer cells in the S-phase, thereby controlling cell growth. Additionally, telmisartan influences receptor tyrosine kinases, specifically ErbB3, which plays a role in cellular proliferation. The potential for telmisartan to act against cancer progression, especially in ESCC, highlights its promise beyond hypertension treatment and marks it as a candidate for targeted cancer therapies.
Matsui, T., Chiyo, T., Kobara, H., Fujihara, S., Fujita, K., Namima, D., Nakahara, M., Kobayashi, N., Nishiyama, N., Yachida, T., Morishita, A., Iwama, H., and Masaki, T. (2019) Telmisartan inhibits cell proliferation and tumor growth of esophageal squamous cell carcinoma by inducing S-phase arrest in vitro and in vivo', International Journal of Molecular Sciences.
Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.
For detailed information about Sartanos 20 by Driada Medical, consult with your doctor or healthcare professional.
Matsui, T., Chiyo, T., Kobara, H., Fujihara, S., Fujita, K., Namima, D., Nakahara, M., Kobayashi, N., Nishiyama, N., Yachida, T., Morishita, A., Iwama, H., and Masaki, T. (2019) Telmisartan inhibits cell proliferation and tumor growth of esophageal squamous cell carcinoma by inducing S-phase arrest in vitro and in vivo', International Journal of Molecular Sciences.
Matsui, T., Chiyo, T., Kobara, H., Fujihara, S., Fujita, K., Namima, D., Nakahara, M., Kobayashi, N., Nishiyama, N., Yachida, T., Morishita, A., Iwama, H., and Masaki, T. (2019) Telmisartan inhibits cell proliferation and tumor growth of esophageal squamous cell carcinoma by inducing S-phase arrest in vitro and in vivo', International Journal of Molecular Sciences.
Matsui, T., Chiyo, T., Kobara, H., Fujihara, S., Fujita, K., Namima, D., Nakahara, M., Kobayashi, N., Nishiyama, N., Yachida, T., Morishita, A., Iwama, H., and Masaki, T. (2019) Telmisartan inhibits cell proliferation and tumor growth of esophageal squamous cell carcinoma by inducing S-phase arrest in vitro and in vivo', International Journal of Molecular Sciences.
Home
