Bremelanotide, sold as Vyleesi, is an FDA-approved option for treating hypoactive sexual desire disorder (HSDD) in premenopausal women. It activates melanocortin 1 and 4 receptors in the hypothalamus, linked to arousal and behavioral responses, triggering dopamine release to boost desire. Administered roughly 45 minutes before anticipated intimacy, this receptor-targeting therapy shows promise in enhancing desire and alleviating distress. While its precise action remains under investigation, research highlights its effectiveness in addressing low sexual drive, offering improved arousal and overall satisfaction for affected women.
Hall, K. S. K., & Binik, Y. M. (2020). Principles and practice of sex therapy (6th ed.). The Guilford Press.
Paauw, D. (2024). Newer outpatient therapies and treatments, an issue of Medical Clinics of North America. Elsevier.
Stahl, S.M., 2020. Prescriber's Guide: Stahl's Essential Psychopharmacology. United Kingdom: Cambridge University Press.
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Stahl, S.M., 2020. Prescriber's Guide: Stahl's Essential Psychopharmacology. United Kingdom: Cambridge University Press.
Stahl, S.M., 2020. Prescriber's Guide: Stahl's Essential Psychopharmacology. United Kingdom: Cambridge University Press.
Stahl, S.M., 2020. Prescriber's Guide: Stahl's Essential Psychopharmacology. United Kingdom: Cambridge University Press.