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Bremelanotide (PT-141)

Bremelanotide (PT-141)

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Substance Overview and History

In June 2019 the FDA approved Bremelanotide (sold under the brand name Vyleesi) as a treatment, for desire in premenopausal women diagnosed with acquired generalized hypoactive sexual desire disorder (HSDD). Its distinctive administration method and side effect profile have sparked interest in comparison, to flibanserin. While the precise way it works isn't entirely known yet bremelanotide triggers certain brain chemicals linked to arousal by attaching to receptors, in the brain that influence sexual behavior. The activation triggers the release of dopamine enhancing stimulating signals. Bremelanotide should be taken 45 minutes prior to engaging in sexual activity however the best timing, for its use is still not clearly defined. When successful, in its application it enhances levels of desire and lessens the emotional turmoil associated with sexual issues.

References:

Hall, K. S. K., & Binik, Y. M. (2020). Principles and practice of sex therapy (6th ed.). The Guilford Press.

Paauw, D. (2024). Newer outpatient therapies and treatments, an issue of Medical Clinics of North America. Elsevier.

Stahl, S.M., 2020. Prescriber's Guide: Stahl's Essential Psychopharmacology. United Kingdom: Cambridge University Press.

Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.

For more details consult with your doctor or healthcare professional.

FAQ
What is Bremelanotide (Vyleesi)?
Bremelanotide (Vyleesi) is a melanocortin receptor agonist approved by the FDA in 2019 to treat low sexual desire in premenopausal women with HSDD.
The way does Bremelanotide work?
It activates receptors, like melanocortin 1 and 4 that play a role, in arousal.
References:

Stahl, S.M., 2020. Prescriber's Guide: Stahl's Essential Psychopharmacology. United Kingdom: Cambridge University Press.

What is Bremelanotide prescribed for?
It is prescribed for acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women.
References:

Stahl, S.M., 2020. Prescriber's Guide: Stahl's Essential Psychopharmacology. United Kingdom: Cambridge University Press.