PNC-27 is a chimeric peptide derived from the p53 protein that aims to selectively lyse cancer cell membranes. This peptide induces fast necrosis through the creation of transmembrane pores in result distinguishing its action from traditional apoptosis. Efficacy is linked to its binding with HDM-2, a protein frequently found in elevated levels on cancer cells. By targeting this protein while avoiding normal cells PNC-27 offers a tailored approach to cancer treatment, supported by its amphipathic alpha-helix structure that facilitates membrane interactions.
Sarafraz-Yazdi, E., Mumin, S., Cheung, D., Fridman, D., Lin, B., Wong, L., Rosal, R., Rudolph, R., Frenkel, M., Thadi, A., Morano, W.F., Bowne, W.B., Pincus, M.R., and Michl, J. (2022). PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis. Biomedicines.
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For detailed information about PNC-27 by Deus Medical, consult with your doctor or healthcare professional.
Sarafraz-Yazdi, E., Mumin, S., Cheung, D., Fridman, D., Lin, B., Wong, L., Rosal, R., Rudolph, R., Frenkel, M., Thadi, A., Morano, W.F., Bowne, W.B., Pincus, M.R., and Michl, J. (2022). PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis. Biomedicines.
Sarafraz-Yazdi, E., Mumin, S., Cheung, D., Fridman, D., Lin, B., Wong, L., Rosal, R., Rudolph, R., Frenkel, M., Thadi, A., Morano, W.F., Bowne, W.B., Pincus, M.R., and Michl, J. (2022). PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis. Biomedicines.
Sarafraz-Yazdi, E., Mumin, S., Cheung, D., Fridman, D., Lin, B., Wong, L., Rosal, R., Rudolph, R., Frenkel, M., Thadi, A., Morano, W.F., Bowne, W.B., Pincus, M.R., and Michl, J. (2022). PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis. Biomedicines.
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