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Anti-cancer peptide (PNC-27)

Anti-cancer peptide (PNC-27)

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PNC-27
Deus Medical
Substance Overview and History

PNC-27 is an exciting peptide developed from the p53 protein is designed specifically to target and destroy cancer cells. Works by creating small holes in the membranes of these cells, leading to cell death. This process is driven by PNC-27's ability to connect with HDM-2, a protein that is found in higher amounts in many cancer cells. Since normal cells have much lower levels of HDM-2, they are not affected. The structure which features an amphipathic alpha-helix, improves its potency in targeting cancer cells.

References:

Sarafraz-Yazdi, E., Mumin, S., Cheung, D., Fridman, D., Lin, B., Wong, L., Rosal, R., Rudolph, R., Frenkel, M., Thadi, A., Morano, W.F., Bowne, W.B., Pincus, M.R., and Michl, J. (2022). PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis. Biomedicines.

Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.

For more details consult with your doctor or healthcare professional.

FAQ
What is PNC-27?
PNC-27 Is a type of peptide that targets and destroys cancer cells by rupturing their cell membranes.
References:

Sarafraz-Yazdi, E., Mumin, S., Cheung, D., Fridman, D., Lin, B., Wong, L., Rosal, R., Rudolph, R., Frenkel, M., Thadi, A., Morano, W.F., Bowne, W.B., Pincus, M.R., and Michl, J. (2022). PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis. Biomedicines.

How does PNC-27 work?
Induces necrosis in cancer cells through the formation of pores in their membranes.
References:

Sarafraz-Yazdi, E., Mumin, S., Cheung, D., Fridman, D., Lin, B., Wong, L., Rosal, R., Rudolph, R., Frenkel, M., Thadi, A., Morano, W.F., Bowne, W.B., Pincus, M.R., and Michl, J. (2022). PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis. Biomedicines.

What is the significance of HDM-2?
HDM-2 is a protein that PNC-27 binds to which is essential for its action against cancer cells.
References:

Sarafraz-Yazdi, E., Mumin, S., Cheung, D., Fridman, D., Lin, B., Wong, L., Rosal, R., Rudolph, R., Frenkel, M., Thadi, A., Morano, W.F., Bowne, W.B., Pincus, M.R., and Michl, J. (2022). PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis. Biomedicines.