Amlodipine is widely used in managing hypertension and cardiovascular conditions, demonstrating additional anti-atherosclerotic effects. By modulating the vascular smooth muscle cell (VSMC) phenotype, it prevents pathological remodeling associated with hypertension. Amlodipine enhances miR-21 expression, which supports VSMC differentiation and reduces oxidative stress, showcasing its multifaceted role in cardiovascular health.
Fang, Q., Tian, M., Wang, F., Zhang, Z., Du, T., Wang, W., Yang, Y., Li, X., Chen, G., Xiao, L., Wei, H., Wang, Y., Chen, C. and Wang, D.W., 2019. Amlodipine induces vasodilation via Akt2/Sp1‐activated miR‐21 in smooth muscle cells. British Journal of Pharmacology
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Fang, Q., Tian, M., Wang, F., Zhang, Z., Du, T., Wang, W., Yang, Y., Li, X., Chen, G., Xiao, L., Wei, H., Wang, Y., Chen, C. and Wang, D.W., 2019. Amlodipine induces vasodilation via Akt2/Sp1‐activated miR‐21 in smooth muscle cells. British Journal of Pharmacology
Fang, Q., Tian, M., Wang, F., Zhang, Z., Du, T., Wang, W., Yang, Y., Li, X., Chen, G., Xiao, L., Wei, H., Wang, Y., Chen, C. and Wang, D.W., 2019. Amlodipine induces vasodilation via Akt2/Sp1‐activated miR‐21 in smooth muscle cells. British Journal of Pharmacology
Fang, Q., Tian, M., Wang, F., Zhang, Z., Du, T., Wang, W., Yang, Y., Li, X., Chen, G., Xiao, L., Wei, H., Wang, Y., Chen, C. and Wang, D.W., 2019. Amlodipine induces vasodilation via Akt2/Sp1‐activated miR‐21 in smooth muscle cells. British Journal of Pharmacology
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