Amlodipine, a third-generation dihydropyridine calcium channel blocker, effectively lowers blood pressure and reduces cardiovascular risks. Beyond its antihypertensive properties, it provides anti-atherosclerotic benefits, reducing ischemic episodes and the need for revascularization. Amlodipine also regulates vascular smooth muscle cell (VSMC) behavior, inhibiting proliferation and promoting a contractile phenotype, crucial for vascular health in hypertensive patients.
Fang, Q., Tian, M., Wang, F., Zhang, Z., Du, T., Wang, W., Yang, Y., Li, X., Chen, G., Xiao, L., Wei, H., Wang, Y., Chen, C. and Wang, D.W., 2019. Amlodipine induces vasodilation via Akt2/Sp1‐activated miR‐21 in smooth muscle cells. British Journal of Pharmacology
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Fang, Q., Tian, M., Wang, F., Zhang, Z., Du, T., Wang, W., Yang, Y., Li, X., Chen, G., Xiao, L., Wei, H., Wang, Y., Chen, C. and Wang, D.W., 2019. Amlodipine induces vasodilation via Akt2/Sp1‐activated miR‐21 in smooth muscle cells. British Journal of Pharmacology
Fang, Q., Tian, M., Wang, F., Zhang, Z., Du, T., Wang, W., Yang, Y., Li, X., Chen, G., Xiao, L., Wei, H., Wang, Y., Chen, C. and Wang, D.W., 2019. Amlodipine induces vasodilation via Akt2/Sp1‐activated miR‐21 in smooth muscle cells. British Journal of Pharmacology
Fang, Q., Tian, M., Wang, F., Zhang, Z., Du, T., Wang, W., Yang, Y., Li, X., Chen, G., Xiao, L., Wei, H., Wang, Y., Chen, C. and Wang, D.W., 2019. Amlodipine induces vasodilation via Akt2/Sp1‐activated miR‐21 in smooth muscle cells. British Journal of Pharmacology
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