Recognized for its broad cardiovascular benefits, amlodipine not only controls blood pressure but also mitigates risks of unstable angina and myocardial ischemia. It inhibits VSMC proliferation, a key factor in vascular remodeling, by targeting G1-phase cell cycle progression. Additionally, it influences microRNA pathways, such as miR-21, to maintain healthy vascular smooth muscle function, offering protection against vascular diseases.
Fang, Q., Tian, M., Wang, F., Zhang, Z., Du, T., Wang, W., Yang, Y., Li, X., Chen, G., Xiao, L., Wei, H., Wang, Y., Chen, C. and Wang, D.W., 2019. Amlodipine induces vasodilation via Akt2/Sp1‐activated miR‐21 in smooth muscle cells. British Journal of Pharmacology
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Fang, Q., Tian, M., Wang, F., Zhang, Z., Du, T., Wang, W., Yang, Y., Li, X., Chen, G., Xiao, L., Wei, H., Wang, Y., Chen, C. and Wang, D.W., 2019. Amlodipine induces vasodilation via Akt2/Sp1‐activated miR‐21 in smooth muscle cells. British Journal of Pharmacology
Fang, Q., Tian, M., Wang, F., Zhang, Z., Du, T., Wang, W., Yang, Y., Li, X., Chen, G., Xiao, L., Wei, H., Wang, Y., Chen, C. and Wang, D.W., 2019. Amlodipine induces vasodilation via Akt2/Sp1‐activated miR‐21 in smooth muscle cells. British Journal of Pharmacology
Fang, Q., Tian, M., Wang, F., Zhang, Z., Du, T., Wang, W., Yang, Y., Li, X., Chen, G., Xiao, L., Wei, H., Wang, Y., Chen, C. and Wang, D.W., 2019. Amlodipine induces vasodilation via Akt2/Sp1‐activated miR‐21 in smooth muscle cells. British Journal of Pharmacology
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