IGF1 LR3 - Hubio Pharm

Insulin-like Growth Factor-1 DES is a modified IGF-1 molecule missing three amino acids at its N-terminus, significantly altering its function. Its weaker binding to IGFBPs results in greater tissue availability and stronger cellular effects. Though highly active in vitro, its neuroprotective effects are dose-dependent in vivo, with low doses ineffective and high doses showing a protective trend. Studies suggest IGF-1’s full benefits depend on binding protein interaction, which IGF-1 DES lacks, making it a unique but complex candidate for regenerative and CNS-related applications

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