Tesofensine is a triple monoamine re-uptake inhibitor that targets dopamine, serotonin, and norepinephrine, reducing appetite and boosting metabolism. Studies show it significantly lowers daily food intake, leading to sustained weight loss without weight rebound. It also reduces cravings for sweet foods, offering dual benefits as an appetite suppressant and metabolic enhancer. Interestingly, its effects are more pronounced in high-fat-fed subjects, indicating a targeted mechanism for obesity treatment. Additionally, tesofensine affects specific brain regions linked to feeding behavior, suggesting broader therapeutic potential
Perez, C.I., Luis-Islas, J., Lopez, A., Diaz, X., Molina, O., Arroyo, B., Moreno, M.G., Gil Lievana, E., Fonseca, E., Castañeda-Hernández, G. and Gutierrez, R., 2024. Tesofensine, a novel antiobesity drug, silences GABAergic hypothalamic neurons. PLoS One
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Perez, C.I., Luis-Islas, J., Lopez, A., Diaz, X., Molina, O., Arroyo, B., Moreno, M.G., Gil Lievana, E., Fonseca, E., Castañeda-Hernández, G. and Gutierrez, R., 2024. Tesofensine, a novel antiobesity drug, silences GABAergic hypothalamic neurons. PLoS One
Perez, C.I., Luis-Islas, J., Lopez, A., Diaz, X., Molina, O., Arroyo, B., Moreno, M.G., Gil Lievana, E., Fonseca, E., Castañeda-Hernández, G. and Gutierrez, R., 2024. Tesofensine, a novel antiobesity drug, silences GABAergic hypothalamic neurons. PLoS One
Perez, C.I., Luis-Islas, J., Lopez, A., Diaz, X., Molina, O., Arroyo, B., Moreno, M.G., Gil Lievana, E., Fonseca, E., Castañeda-Hernández, G. and Gutierrez, R., 2024. Tesofensine, a novel antiobesity drug, silences GABAergic hypothalamic neurons. PLoS One
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