Selank, a glyprolin neuropeptide, demonstrates a unique ability to manage stress-induced inflammation and modulate immune response, according to recent studies. Originally, the production of pro-inflammatory cytokines like IL-1β and IL-6 was thought to be purely a response to inflammation and immune activation. However, new data suggests that these cytokines can also be triggered by stress, leading to immune and inflammatory responses that can affect various cell types, including neurons and immunocompetent cells. Selank has been shown to reduce the production of key inflammatory cytokines under conditions of social stress, such as IL-1β, IL-6, TGF-β1, and TNF-α, while restoring IL-4 levels, an anti-inflammatory cytokine. In controlled experiments with rats experiencing social stress from daily confrontations, Selank significantly decreased IL-1β and IL-6 levels compared to stressed animals not receiving treatment. Moreover, it prevented a notable rise in TGF-β1 and TNF-α, two cytokines associated with immune and inflammatory responses under stress. The results suggest that Selank’s stress-protective effects involve restoring cytokine balance, which in turn may help maintain immune and neurological health under stress. These findings emphasize Selank’s therapeutic potential in managing stress-related immune changes and inflammation, pointing to its broader application in stress-related immune modulation and anti-inflammatory treatments.
Leonidovna, YA., Aleksandrovna, SM., Aleksandrovna, TA., Aleksandrovna, BO., Fedorovich, MN., Aleksandrovna, AL. (2021). The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress. Curr Rev Clin Exp Pharmacol.
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Leonidovna, YA., Aleksandrovna, SM., Aleksandrovna, TA., Aleksandrovna, BO., Fedorovich, MN., Aleksandrovna, AL. (2021). The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress. Curr Rev Clin Exp Pharmacol.
Leonidovna, YA., Aleksandrovna, SM., Aleksandrovna, TA., Aleksandrovna, BO., Fedorovich, MN., Aleksandrovna, AL. (2021). The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress. Curr Rev Clin Exp Pharmacol.
Leonidovna, YA., Aleksandrovna, SM., Aleksandrovna, TA., Aleksandrovna, BO., Fedorovich, MN., Aleksandrovna, AL. (2021). The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress. Curr Rev Clin Exp Pharmacol.