Retatrutide is an investigational therapy offering hope for metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease. As obesity rates climb, so does the prevalence of MASLD, a condition driven by insulin resistance that leads to fat accumulation in the liver. Over time, MASLD can progress to a more severe stage, metabolic dysfunction-associated steatohepatitis (MASH), which may lead to cirrhosis or even the need for liver transplantation. Retatrutide is a novel treatment targeting three key metabolic pathways through human GIP, GLP-1, and glucagon receptors, making it highly effective for liver health. In clinical trials, it significantly reduced liver fat and improved metabolic health markers, offering a much-needed potential treatment for MASLD. If successful, Retatrutide could become a critical tool for managing MASLD and MASH, conditions with limited current treatment options.
Sanyal, A.J., Kaplan, L.M., Frias, J.P., Brouwers, B., Wu, Q., Thomas, M.K., Harris, C., Schloot, N.C., Du, Y., Mather, K.J., Haupt, A., and Hartman, M.L., 2024. Retatrutide effects on liver fat and metabolic outcomes in patients with MASLD. Nature Medicine.
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Sanyal, A.J., Kaplan, L.M., Frias, J.P., Brouwers, B., Wu, Q., Thomas, M.K., Harris, C., Schloot, N.C., Du, Y., Mather, K.J., Haupt, A., and Hartman, M.L., 2024. Retatrutide effects on liver fat and metabolic outcomes in patients with MASLD. Nature Medicine.
Sanyal, A.J., Kaplan, L.M., Frias, J.P., Brouwers, B., Wu, Q., Thomas, M.K., Harris, C., Schloot, N.C., Du, Y., Mather, K.J., Haupt, A., and Hartman, M.L., 2024. Retatrutide effects on liver fat and metabolic outcomes in patients with MASLD. Nature Medicine.
Sanyal, A.J., Kaplan, L.M., Frias, J.P., Brouwers, B., Wu, Q., Thomas, M.K., Harris, C., Schloot, N.C., Du, Y., Mather, K.J., Haupt, A., and Hartman, M.L., 2024. Retatrutide effects on liver fat and metabolic outcomes in patients with MASLD. Nature Medicine.