Combination of 2 compounds: As a groundbreaking treatment for ED, tadalafil offers unmatched duration of action, lasting up to 36 hours. This extended effect is due to its unique β-carboline structure, which ensures a prolonged half-life. Its introduction in 2003 provided patients with a versatile and effective option for managing erectile dysfunction. Through computational screening and in vitro validation, dapoxetine has been identified as a promising anti-Zika virus agent. It binds effectively to ZIKV RdRp, hindering viral RNA synthesis and reducing infection in various cell models. Its capacity to inhibit NS5 and E protein expression underscores its mechanism of action. With an EC50 below 15 µM and low cytotoxicity, dapoxetine combines efficacy and safety. These results advocate further research into its potential clinical applications for ZIKV, particularly in sensitive demographics such as pregnant women and infants.
Coward, R.M. & Carson, C.C., 2008. Tadalafil in the treatment of erectile dysfunction. Therapeutics and Clinical Risk Management.
Zhang, B., Yu, J., Zhu, G., Huang, Y., Zhang, K., Xiao, X., He, W., Yuan, J., Gao, X. (2023) 'Dapoxetine, a Selective Serotonin Reuptake Inhibitor, Suppresses Zika Virus Infection In Vitro', Molecules.
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Zhang, B., Yu, J., Zhu, G., Huang, Y., Zhang, K., Xiao, X., He, W., Yuan, J., Gao, X. (2023) 'Dapoxetine, a Selective Serotonin Reuptake Inhibitor, Suppresses Zika Virus Infection In Vitro', Molecules.
Zhang, B., Yu, J., Zhu, G., Huang, Y., Zhang, K., Xiao, X., He, W., Yuan, J., Gao, X. (2023) 'Dapoxetine, a Selective Serotonin Reuptake Inhibitor, Suppresses Zika Virus Infection In Vitro', Molecules.
Coward, R.M. & Carson, C.C., 2008. Tadalafil in the treatment of erectile dysfunction. Therapeutics and Clinical Risk Management.