Dapoxetine

Dapoxetine, developed by Eli Lilly and approved by the EMEA in 2009, is the first drug specifically created for treating premature ejaculation (PE) in men. Marketed as Priligy, it belongs to the selective serotonin reuptake inhibitor (SSRI) class. Unlike other SSRIs, dapoxetine acts quickly and is used on-demand. It works by increasing serotonin activity in the brain, helping delay ejaculation and improving sexual performance. Studies show that dapoxetine can extend time to ejaculation by 1-2 minutes. Dapoxetine is designed to be taken 1-3 hours before sexual activity, with effects usually felt within an hour. The drug reaches peak plasma concentration in 1-2 hours and, due to its short half-life, is rapidly eliminated from the body, making it suitable for as-needed use rather than continuous daily treatment. Potential side effects include sexual and cardiovascular dysfunctions. Dapoxetine should not be taken with other SSRIs, antidepressants, sedatives, or recreational drugs due to possible interactions.

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