Dapoxetine, an FDA-approved SSRI initially developed for premature ejaculation, has shown potential as an anti-Zika virus (ZIKV) therapeutic. It targets the ZIKV RNA-dependent RNA polymerase (RdRp), inhibiting RNA replication by binding to the “N” pocket within the RdRp priming loop. In vitro assays revealed dose-dependent antiviral effects with EC50 values between 4.2 μM and 12.6 μM, effectively reducing ZIKV titers and viral proteins. With minimal cytotoxicity and established clinical safety, dapoxetine emerges as a promising candidate for repurposing against ZIKV and potentially other RNA viruses .
Zhang, B., Yu, J., Zhu, G., Huang, Y., Zhang, K., Xiao, X., He, W., Yuan, J., Gao, X. (2023) 'Dapoxetine, a Selective Serotonin Reuptake Inhibitor, Suppresses Zika Virus Infection In Vitro', Molecules.
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For detailed information about Dapoxetinos 30 by Driada Medical, consult with your doctor or healthcare professional.
Zhang, B., Yu, J., Zhu, G., Huang, Y., Zhang, K., Xiao, X., He, W., Yuan, J., Gao, X. (2023) 'Dapoxetine, a Selective Serotonin Reuptake Inhibitor, Suppresses Zika Virus Infection In Vitro', Molecules.
Zhang, B., Yu, J., Zhu, G., Huang, Y., Zhang, K., Xiao, X., He, W., Yuan, J., Gao, X. (2023) 'Dapoxetine, a Selective Serotonin Reuptake Inhibitor, Suppresses Zika Virus Infection In Vitro', Molecules.
Zhang, B., Yu, J., Zhu, G., Huang, Y., Zhang, K., Xiao, X., He, W., Yuan, J., Gao, X. (2023) 'Dapoxetine, a Selective Serotonin Reuptake Inhibitor, Suppresses Zika Virus Infection In Vitro', Molecules.
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