Known for its stimulant and aphrodisiac effects, yohimbine is an indole alkaloid primarily sourced from African trees such as Pausinystalia johimbe. Its role as an alpha-2 receptor antagonist has made it a well-regarded treatment for erectile dysfunction for decades, and its effects reach both central and peripheral nervous systems. Besides sexual health, yohimbine shows promise in treating hyperadrenergic conditions like myocardial and inflammatory disorders. This compound interacts with multiple receptors, including serotonin and dopamine receptors, lending itself to a broader scope of research. Clinical interest in yohimbine is partly driven by its molecular complexity, which includes stereoisomers like rauwolscine, and ongoing studies aim to assess safer formulations with fewer side effects.
Jabir, N.R., Firoz, C.K., Zughaibi, T.A., Alsaadi, M.A., Abuzenadah, A.M., Al-Asmari, A.I., Alsaieedi, A., Ahmed, B.A. and Ramu, A.K., 2022. A literature perspective on the pharmacological applications of yohimbine. Annals of Medicine.
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Jabir, N.R., Firoz, C.K., Zughaibi, T.A., Alsaadi, M.A., Abuzenadah, A.M., Al-Asmari, A.I., Alsaieedi, A., Ahmed, B.A. and Ramu, A.K., 2022. A literature perspective on the pharmacological applications of yohimbine. Annals of Medicine.
Jabir, N.R., Firoz, C.K., Zughaibi, T.A., Alsaadi, M.A., Abuzenadah, A.M., Al-Asmari, A.I., Alsaieedi, A., Ahmed, B.A. and Ramu, A.K., 2022. A literature perspective on the pharmacological applications of yohimbine. Annals of Medicine.
Jabir, N.R., Firoz, C.K., Zughaibi, T.A., Alsaadi, M.A., Abuzenadah, A.M., Al-Asmari, A.I., Alsaieedi, A., Ahmed, B.A. and Ramu, A.K., 2022. A literature perspective on the pharmacological applications of yohimbine. Annals of Medicine.