Melanotan-II (MT-II) is a synthetic cyclic heptapeptide originally created as a tanning agent. Based on Melanotan-I, MT-II’s design includes a cyclization that enhances stability, allowing it to resist breakdown in the body. This structure enables MT-II to bind effectively to melanocortin receptors, specifically MC1R, MC3R, and MC4R, with a particularly strong affinity for MC4R. Due to this, MT-II is considered "superpotent" and can cross the blood-brain barrier. Its action on MC4R receptors not only affects skin pigmentation but also has proerectile properties, which were discovered accidentally during early studies. MT-II’s capability to initiate erections through central mechanisms rather than peripheral effects led to its exploration as an alternative for erectile dysfunction.
King, S.H., Mayorov, A.V., Balse-Srinivasan, P., Hruby, V.J., Vanderah, T.W., and Wessells, H. (2007). Melanocortin receptors, melanotropic peptides and penile erection. Current Topics in Medicinal Chemistry.
Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.
For detailed information about Intex MT2 by Intex Pharma, consult with your doctor or healthcare professional.
King, S.H., Mayorov, A.V., Balse-Srinivasan, P., Hruby, V.J., Vanderah, T.W., and Wessells, H. (2007). Melanocortin receptors, melanotropic peptides and penile erection. Current Topics in Medicinal Chemistry.
King, S.H., Mayorov, A.V., Balse-Srinivasan, P., Hruby, V.J., Vanderah, T.W., and Wessells, H. (2007). Melanocortin receptors, melanotropic peptides and penile erection. Current Topics in Medicinal Chemistry.
King, S.H., Mayorov, A.V., Balse-Srinivasan, P., Hruby, V.J., Vanderah, T.W., and Wessells, H. (2007). Melanocortin receptors, melanotropic peptides and penile erection. Current Topics in Medicinal Chemistry.
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