Viagra, or sildenafil citrate, emerged from Pfizer’s research into antianginal drugs in the late 1980s. It works by enhancing nitric oxide signaling and preserving cGMP levels via PDE5 inhibition. Though ineffective for long-term angina treatment, it became a breakthrough therapy for erectile dysfunction after clinical trials showed significant improvements in sexual function. Approved in 1998, Viagra quickly became the leading ED medication, with millions of prescriptions filled worldwide and a strong safety record.
Dunzendorfer, U. (2012) Sildenafil. Switzerland: Birkhäuser Basel.
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Dunzendorfer, U. (2012) Sildenafil. Switzerland: Birkhäuser Basel.
Dunzendorfer, U. (2012) Sildenafil. Switzerland: Birkhäuser Basel.
Dunzendorfer, U. (2012) Sildenafil. Switzerland: Birkhäuser Basel.