Yohimbine is a potent stimulant and aphrodisiac derived from the bark of trees like Pausinystalia johimbe and Rauvolfia. Recognized since the 1950s in Canada and the late 1970s in Germany, it’s licensed to treat erectile dysfunction by acting as an alpha-2 receptor antagonist. Yohimbine promotes hyperadrenergic effects, boosting both central and peripheral nervous systems, and enhancing blood flow to promote improved sexual function. Commonly, the pure form of yohimbine is taken in doses of 5 to 10 mg three times a day, though side effects may include transient symptoms such as elevated blood pressure, perspiration, and anxiety. With an intricate structure featuring five chiral centers, yohimbine also interacts with dopamine and serotonin receptors, creating a complex biochemical profile that continues to attract scientific interest for further potential in addressing cardiovascular and inflammatory conditions.
Jabir, N.R., Firoz, C.K., Zughaibi, T.A., Alsaadi, M.A., Abuzenadah, A.M., Al-Asmari, A.I., Alsaieedi, A., Ahmed, B.A. and Ramu, A.K., 2022. A literature perspective on the pharmacological applications of yohimbine. Annals of Medicine.
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Jabir, N.R., Firoz, C.K., Zughaibi, T.A., Alsaadi, M.A., Abuzenadah, A.M., Al-Asmari, A.I., Alsaieedi, A., Ahmed, B.A. and Ramu, A.K., 2022. A literature perspective on the pharmacological applications of yohimbine. Annals of Medicine.
Jabir, N.R., Firoz, C.K., Zughaibi, T.A., Alsaadi, M.A., Abuzenadah, A.M., Al-Asmari, A.I., Alsaieedi, A., Ahmed, B.A. and Ramu, A.K., 2022. A literature perspective on the pharmacological applications of yohimbine. Annals of Medicine.
Jabir, N.R., Firoz, C.K., Zughaibi, T.A., Alsaadi, M.A., Abuzenadah, A.M., Al-Asmari, A.I., Alsaieedi, A., Ahmed, B.A. and Ramu, A.K., 2022. A literature perspective on the pharmacological applications of yohimbine. Annals of Medicine.