Synthesized in 1989 by Pfizer, Sildenafil was originally researched for cardiovascular purposes, specifically angina. By inhibiting PDE5, Sildenafil preserves cGMP levels, promoting smooth muscle relaxation and enhancing blood flow, which benefits erectile function. Approved in 1998 as Viagra, it was the first oral medication for ED and achieved global acclaim. Its efficacy, safety, and well-tolerated profile make Sildenafil a trusted therapy, and its market success has spurred the development of alternative PDE5 inhibitors, although Viagra remains the gold standard for ED treatment.
Dunzendorfer, U. (2012) Sildenafil. Switzerland: Birkhäuser Basel.
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Dunzendorfer, U. (2012) Sildenafil. Switzerland: Birkhäuser Basel.
Dunzendorfer, U. (2012) Sildenafil. Switzerland: Birkhäuser Basel.
Dunzendorfer, U. (2012) Sildenafil. Switzerland: Birkhäuser Basel.