Tesofensine, a potent triple monoamine reuptake inhibitor, is emerging as a promising approach for obesity management by influencing key neurotransmitters involved in appetite and energy regulation. Unlike conventional weight loss treatments, which often rely on diet and exercise alone, tesofensine inhibits dopamine, serotonin, and norepinephrine reuptake, driving significant reductions in food intake and promoting sustained weight loss. Studies show its effectiveness in lowering daily calorie consumption, as observed in both animal and human models. Notably, tesofensine combines appetite suppression with enhanced energy expenditure, making it an effective dual-action treatment. Its action may target the lateral hypothalamus, a key brain region for hunger signals, offering a more comprehensive and long-term obesity solution.
Perez, C.I., Luis-Islas, J., Lopez, A., Diaz, X., Molina, O., Arroyo, B., Moreno, M.G., Gil Lievana, E., Fonseca, E., Castañeda-Hernández, G. and Gutierrez, R., 2024. Tesofensine, a novel antiobesity drug, silences GABAergic hypothalamic neurons. PLoS One
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Perez, C.I., Luis-Islas, J., Lopez, A., Diaz, X., Molina, O., Arroyo, B., Moreno, M.G., Gil Lievana, E., Fonseca, E., Castañeda-Hernández, G. and Gutierrez, R., 2024. Tesofensine, a novel antiobesity drug, silences GABAergic hypothalamic neurons. PLoS One
Perez, C.I., Luis-Islas, J., Lopez, A., Diaz, X., Molina, O., Arroyo, B., Moreno, M.G., Gil Lievana, E., Fonseca, E., Castañeda-Hernández, G. and Gutierrez, R., 2024. Tesofensine, a novel antiobesity drug, silences GABAergic hypothalamic neurons. PLoS One
Perez, C.I., Luis-Islas, J., Lopez, A., Diaz, X., Molina, O., Arroyo, B., Moreno, M.G., Gil Lievana, E., Fonseca, E., Castañeda-Hernández, G. and Gutierrez, R., 2024. Tesofensine, a novel antiobesity drug, silences GABAergic hypothalamic neurons. PLoS One