5-Amino-1MQ targets the nicotinamide N-methyltransferase (NNMT) enzyme, which plays a role in metabolic regulation and fat storage. Studies show that it effectively reduces body weight and adipose tissue mass in high-fat diet-induced obese mice. Additionally, it improves cellular energy metabolism by enhancing NAD+ levels and modulating pathways critical to adipocyte differentiation. With its selective and membrane-permeable properties, 5-Amino-1MQ not only reduces obesity-related complications but also supports metabolic health, making it a potential therapeutic option for obesity treatment.
Neelakantan, H., Vance, V., Wetzel, M.D., Wang, H.Y.L., McHardy, S.F., Finnerty, C.C., Hommel, J.D., and Watowich, S.J., 2018. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat diet-induced obesity in mice. Biochemical Pharmacology.
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For detailed information about 5-Amino 1MQ 50 by Beligas Pharmaceuticals, consult with your doctor or healthcare professional.
Neelakantan, H., Vance, V., Wetzel, M.D., Wang, H.Y.L., McHardy, S.F., Finnerty, C.C., Hommel, J.D., and Watowich, S.J., 2018. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat diet-induced obesity in mice. Biochemical Pharmacology.
Neelakantan, H., Vance, V., Wetzel, M.D., Wang, H.Y.L., McHardy, S.F., Finnerty, C.C., Hommel, J.D., and Watowich, S.J., 2018. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat diet-induced obesity in mice. Biochemical Pharmacology.
Neelakantan, H., Vance, V., Wetzel, M.D., Wang, H.Y.L., McHardy, S.F., Finnerty, C.C., Hommel, J.D., and Watowich, S.J., 2018. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat diet-induced obesity in mice. Biochemical Pharmacology.
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