5-Amino-1MQ is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme associated with metabolic dysfunction and obesity. It has demonstrated significant potential in reversing high-fat diet-induced obesity in preclinical models by reducing fat accumulation and promoting healthier adipocyte function. In diet-induced obese mice, treatment with 5-Amino-1MQ decreased epididymal white adipose tissue weight, reduced adipocyte size, and improved overall metabolic profiles. The compound’s ability to penetrate cellular membranes and inhibit NNMT makes it a promising candidate for managing obesity and related metabolic disorders.
Neelakantan, H., Vance, V., Wetzel, M.D., Wang, H.Y.L., McHardy, S.F., Finnerty, C.C., Hommel, J.D., and Watowich, S.J., 2018. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat diet-induced obesity in mice. Biochemical Pharmacology.
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Neelakantan, H., Vance, V., Wetzel, M.D., Wang, H.Y.L., McHardy, S.F., Finnerty, C.C., Hommel, J.D., and Watowich, S.J., 2018. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat diet-induced obesity in mice. Biochemical Pharmacology.
Neelakantan, H., Vance, V., Wetzel, M.D., Wang, H.Y.L., McHardy, S.F., Finnerty, C.C., Hommel, J.D., and Watowich, S.J., 2018. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat diet-induced obesity in mice. Biochemical Pharmacology.
Neelakantan, H., Vance, V., Wetzel, M.D., Wang, H.Y.L., McHardy, S.F., Finnerty, C.C., Hommel, J.D., and Watowich, S.J., 2018. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat diet-induced obesity in mice. Biochemical Pharmacology.
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