HMG is a gonadotropin preparation containing FSH and LH, sourced from postmenopausal urine. It plays a key role in ovarian stimulation for ART procedures. Unlike recombinant FSH, HMG’s dual-hormone content may benefit patients needing added hormonal support. The glycosylation patterns of HMG differ from r-hFSH, influencing hormone activity and treatment outcomes. Research suggests comparable pregnancy rates between both agents, though r-hFSH often retrieves more oocytes. Clinical context, such as age or BMI, is critical in choosing between HMG and other gonadotropins.
Bühler, K.F., Fischer, R., Verpillat, P., Allignol, A., Guedes, S., Boutmy, E., Bilger, W., Richter, E., and D’Hooghe, T., 2021. Comparative effectiveness of recombinant human follicle-stimulating hormone alfa (r-hFSH-alfa) versus highly purified urinary human menopausal gonadotropin (HMG HP) in assisted reproductive technology (ART) treatments: a non-interventional study in Germany. Reproductive Biology and Endocrinology.
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Bühler, K.F., Fischer, R., Verpillat, P., Allignol, A., Guedes, S., Boutmy, E., Bilger, W., Richter, E., and D’Hooghe, T., 2021. Comparative effectiveness of recombinant human follicle-stimulating hormone alfa (r-hFSH-alfa) versus highly purified urinary human menopausal gonadotropin (HMG HP) in assisted reproductive technology (ART) treatments: a non-interventional study in Germany. Reproductive Biology and Endocrinology.
Bühler, K.F., Fischer, R., Verpillat, P., Allignol, A., Guedes, S., Boutmy, E., Bilger, W., Richter, E., and D’Hooghe, T., 2021. Comparative effectiveness of recombinant human follicle-stimulating hormone alfa (r-hFSH-alfa) versus highly purified urinary human menopausal gonadotropin (HMG HP) in assisted reproductive technology (ART) treatments: a non-interventional study in Germany. Reproductive Biology and Endocrinology.
Bühler, K.F., Fischer, R., Verpillat, P., Allignol, A., Guedes, S., Boutmy, E., Bilger, W., Richter, E., and D’Hooghe, T., 2021. Comparative effectiveness of recombinant human follicle-stimulating hormone alfa (r-hFSH-alfa) versus highly purified urinary human menopausal gonadotropin (HMG HP) in assisted reproductive technology (ART) treatments: a non-interventional study in Germany. Reproductive Biology and Endocrinology.