Gonadorelin, an oligopeptide hormone, is synthesized as a decapeptide through advanced solid-phase peptide synthesis. It mirrors the natural gonadotropin-releasing hormone (GnRH) secreted by the hypothalamus. Acting on LHRH receptors in the pituitary gland, gonadorelin induces the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). These hormones regulate essential reproductive processes. The unique ability of gonadorelin to desensitize gonadotropic cells upon continuous use provides a mechanism for reducing gonadotropin secretion. Clinically, it is employed to treat conditions like hypothalamic amenorrhea and to evaluate the functionality of the hypothalamic-pituitary axis, underlining its therapeutic and diagnostic importance.
National Center for Biotechnology Information. "PubChem Compound Summary for CID 638793, Gonadorelin" PubChem
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National Center for Biotechnology Information. "PubChem Compound Summary for CID 638793, Gonadorelin" PubChem
National Center for Biotechnology Information. "PubChem Compound Summary for CID 638793, Gonadorelin" PubChem
National Center for Biotechnology Information. "PubChem Compound Summary for CID 638793, Gonadorelin" PubChem