Gonadorelin

Gonadorelin, a synthetic decapeptide, functions as a gonadotropin-releasing hormone (GnRH) agonist. Comprising ten amino acids joined in sequence, including pyroglutamyl, histidyl, and glycinamide residues, it is synthesized using solid-phase peptide synthesis. Gonadorelin plays a pivotal role in stimulating the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. Acting through transmembrane LHRH receptors on pituitary gonadotropic cells, gonadorelin triggers gonadotropin secretion. However, continuous administration induces desensitization, exerting a negative feedback effect. Clinically, gonadorelin is utilized to manage hypothalamic amenorrhea and to evaluate hypothalamic or pituitary function, reflecting its versatility as a hormone therapy agent.

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