Adipotide is a cutting-edge anti-obesity compound designed to reduce white adipose tissue by disrupting its vascular supply. Through a targeted peptide mechanism, it induces apoptosis in fat tissue blood vessels, sparing other tissues. Research in obese primates demonstrated substantial fat loss, improved metabolic markers like insulin sensitivity, and decreased serum-free fatty acids. The drug bypasses traditional appetite suppression, minimizing neuropsychiatric risks. Although mild renal toxicity occurred, it resolved post-treatment, making adipotide a safe and effective obesity therapy option.
Barnhart, K.F., Christianson, D.R., Hanley, P.W., Driessen, W.H.P., Bernacky, B.J., Baze, W.B., Wen, S., Tian, M., Ma, J., Kolonin, M.G., Saha, P.K., Do, K.A., Hulvat, J.F., Gelovani, J.G., Chan, L., Arap, W., and Pasqualini, R., 2011. A Peptidomimetic Targeting White Fat Causes Weight Loss and Improved Insulin Resistance in Obese Monkeys. Sci Transl Med.
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Barnhart, K.F., Christianson, D.R., Hanley, P.W., Driessen, W.H.P., Bernacky, B.J., Baze, W.B., Wen, S., Tian, M., Ma, J., Kolonin, M.G., Saha, P.K., Do, K.A., Hulvat, J.F., Gelovani, J.G., Chan, L., Arap, W., and Pasqualini, R., 2011. A Peptidomimetic Targeting White Fat Causes Weight Loss and Improved Insulin Resistance in Obese Monkeys. Sci Transl Med.
Barnhart, K.F., Christianson, D.R., Hanley, P.W., Driessen, W.H.P., Bernacky, B.J., Baze, W.B., Wen, S., Tian, M., Ma, J., Kolonin, M.G., Saha, P.K., Do, K.A., Hulvat, J.F., Gelovani, J.G., Chan, L., Arap, W., and Pasqualini, R., 2011. A Peptidomimetic Targeting White Fat Causes Weight Loss and Improved Insulin Resistance in Obese Monkeys. Sci Transl Med.
Barnhart, K.F., Christianson, D.R., Hanley, P.W., Driessen, W.H.P., Bernacky, B.J., Baze, W.B., Wen, S., Tian, M., Ma, J., Kolonin, M.G., Saha, P.K., Do, K.A., Hulvat, J.F., Gelovani, J.G., Chan, L., Arap, W., and Pasqualini, R., 2011. A Peptidomimetic Targeting White Fat Causes Weight Loss and Improved Insulin Resistance in Obese Monkeys. Sci Transl Med.
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