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Adipotide (FTPP)

Adipotide (FTPP)

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FTTP
Ultima Pharmaceuticals
FTTP
Beligas Pharmaceuticals
Substance Overview and History

Adipotide offers a breakthrough in obesity treatment, targeting fat tissue vasculature to achieve rapid weight loss. By inducing apoptosis in white adipose tissue blood vessels, it effectively reduces fat storage. Studies in rhesus monkeys and rodents show significant decreases in body mass index and abdominal fat, alongside improved insulin sensitivity. This targeted approach avoids the side effects linked to central nervous system-targeting drugs. While renal toxicity was noted, it was mild and reversible, making adipotide a promising candidate for tackling obesity's global health burden.

References:

Barnhart, K.F., Christianson, D.R., Hanley, P.W., Driessen, W.H.P., Bernacky, B.J., Baze, W.B., Wen, S., Tian, M., Ma, J., Kolonin, M.G., Saha, P.K., Do, K.A., Hulvat, J.F., Gelovani, J.G., Chan, L., Arap, W., and Pasqualini, R., 2011. A Peptidomimetic Targeting White Fat Causes Weight Loss and Improved Insulin Resistance in Obese Monkeys. Sci Transl Med. 

Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.

For more details consult with your doctor or healthcare professional.

FAQ
What is Adipotide?
Adipotide is an experimental peptide-based anti-obesity drug that targets fat tissue vasculature to induce rapid weight loss by disrupting blood supply to white adipose tissue.
References:

Barnhart, K.F., Christianson, D.R., Hanley, P.W., Driessen, W.H.P., Bernacky, B.J., Baze, W.B., Wen, S., Tian, M., Ma, J., Kolonin, M.G., Saha, P.K., Do, K.A., Hulvat, J.F., Gelovani, J.G., Chan, L., Arap, W., and Pasqualini, R., 2011. A Peptidomimetic Targeting White Fat Causes Weight Loss and Improved Insulin Resistance in Obese Monkeys. Sci Transl Med. 

How does Adipotide work?
It selectively binds to receptors in the blood vessels of white adipose tissue, causing apoptosis and reducing fat tissue.
References:

Barnhart, K.F., Christianson, D.R., Hanley, P.W., Driessen, W.H.P., Bernacky, B.J., Baze, W.B., Wen, S., Tian, M., Ma, J., Kolonin, M.G., Saha, P.K., Do, K.A., Hulvat, J.F., Gelovani, J.G., Chan, L., Arap, W., and Pasqualini, R., 2011. A Peptidomimetic Targeting White Fat Causes Weight Loss and Improved Insulin Resistance in Obese Monkeys. Sci Transl Med. 

What makes Adipotide different from traditional weight loss drugs?
Unlike appetite suppressants, Adipotide works by directly targeting fat cells, avoiding central nervous system effects and minimizing neuropsychiatric side effects.
References:

Barnhart, K.F., Christianson, D.R., Hanley, P.W., Driessen, W.H.P., Bernacky, B.J., Baze, W.B., Wen, S., Tian, M., Ma, J., Kolonin, M.G., Saha, P.K., Do, K.A., Hulvat, J.F., Gelovani, J.G., Chan, L., Arap, W., and Pasqualini, R., 2011. A Peptidomimetic Targeting White Fat Causes Weight Loss and Improved Insulin Resistance in Obese Monkeys. Sci Transl Med.