Designed for men with secondary hypogonadism, enclomiphene citrate promotes natural testosterone production by enhancing gonadotropin release. Acting as a SERM, it counteracts estrogen’s negative feedback on the hypothalamus, boosting LH and FSH levels, crucial for testosterone synthesis and sperm production. Clinical trials reveal enclomiphene’s ability to maintain consistent testosterone levels and improve fertility parameters. Unlike traditional testosterone therapy, it preserves the body’s hormonal balance with limited impact on other hormones like IGF-1, thyroid-stimulating hormone, and cortisol. This makes enclomiphene a promising choice for those prioritizing reproductive health and long-term hormonal stability.
Wiehle, R., Cunningham, G.R., Pitteloud, N., Wike, J., Hsu, K., Fontenot, G.K., Rosner, M., Dwyer, A. and Podolski, J., 2013. Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study. BJU International. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155868/
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Wiehle, R., Cunningham, G.R., Pitteloud, N., Wike, J., Hsu, K., Fontenot, G.K., Rosner, M., Dwyer, A. and Podolski, J., 2013. Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study. BJU International. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155868/
Wiehle, R., Cunningham, G.R., Pitteloud, N., Wike, J., Hsu, K., Fontenot, G.K., Rosner, M., Dwyer, A. and Podolski, J., 2013. Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study. BJU International. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155868/
Wiehle, R., Cunningham, G.R., Pitteloud, N., Wike, J., Hsu, K., Fontenot, G.K., Rosner, M., Dwyer, A. and Podolski, J., 2013. Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study. BJU International. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155868/