Enclomiphene citrate is a selective estrogen receptor modulator that treats secondary hypogonadism by boosting natural testosterone production. Stimulates the release of LH and FSH, leading to increased testosterone levels. Unlike transdermal testosterone, which can suppress these hormones, enclomiphene supports their rise, helping to preserve fertility. Studies show that its effects on testosterone can last for a week after stopping treatment making it a potential option for intermittent dosing and maintaining hormonal balance without continuous use.
Wiehle, R., Cunningham, G.R., Pitteloud, N., Wike, J., Hsu, K., Fontenot, G.K., Rosner, M., Dwyer, A. and Podolski, J., 2013. Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study. BJU International. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155868/
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Wiehle, R., Cunningham, G.R., Pitteloud, N., Wike, J., Hsu, K., Fontenot, G.K., Rosner, M., Dwyer, A. and Podolski, J., 2013. Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study. BJU International. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155868/
Wiehle, R., Cunningham, G.R., Pitteloud, N., Wike, J., Hsu, K., Fontenot, G.K., Rosner, M., Dwyer, A. and Podolski, J., 2013. Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study. BJU International. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155868/
Wiehle, R., Cunningham, G.R., Pitteloud, N., Wike, J., Hsu, K., Fontenot, G.K., Rosner, M., Dwyer, A. and Podolski, J., 2013. Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study. BJU International. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155868/