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Enclomiphene citrate

Enclomiphene citrate

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Substance Overview and History

Enclomiphene citrate is a selective estrogen receptor modulator that treats secondary hypogonadism by boosting natural testosterone production. Stimulates the release of LH and FSH, leading to increased testosterone levels. Unlike transdermal testosterone, which can suppress these hormones, enclomiphene supports their rise, helping to preserve fertility. Studies show that its effects on testosterone can last for a week after stopping treatment making it a potential option for intermittent dosing and maintaining hormonal balance without continuous use.

References:

Wiehle, R., Cunningham, G.R., Pitteloud, N., Wike, J., Hsu, K., Fontenot, G.K., Rosner, M., Dwyer, A. and Podolski, J., 2013. Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study. BJU International. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155868/

Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.

For more details consult with your doctor or healthcare professional.

FAQ
What is Enclomiphene Citrate used for?
Enclomiphene citrate is used to treat secondary hypogonadism in men helping to boost natural testosterone production.
References:

Wiehle, R., Cunningham, G.R., Pitteloud, N., Wike, J., Hsu, K., Fontenot, G.K., Rosner, M., Dwyer, A. and Podolski, J., 2013. Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study. BJU International. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155868/

How does Enclomiphene Citrate differ from transdermal testosterone?
Unlike transdermal testosterone, which can suppress LH and FSH, enclomiphene stimulates these hormones while raising testosterone levels.
References:

Wiehle, R., Cunningham, G.R., Pitteloud, N., Wike, J., Hsu, K., Fontenot, G.K., Rosner, M., Dwyer, A. and Podolski, J., 2013. Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study. BJU International. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155868/

Does Enclomiphene Citrate affect fertility?
Yes it can help preserve or even improve fertility by promoting natural LH and FSH levels, which support sperm production.
References:

Wiehle, R., Cunningham, G.R., Pitteloud, N., Wike, J., Hsu, K., Fontenot, G.K., Rosner, M., Dwyer, A. and Podolski, J., 2013. Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study. BJU International. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155868/