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Valsartan

Valsartan

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Substance Overview and History

Valsartan, a selective angiotensin II type 1 (AT1) receptor blocker, is widely used to manage hypertension and chronic heart failure. It works by blocking the effects of angiotensin II, reducing blood vessel constriction and lowering blood pressure. Beyond its antihypertensive action, valsartan exhibits potential antioxidant and antiglycation properties. It reduces oxidative stress markers, such as reactive oxygen species (ROS) and protein carbonyls, while mitigating advanced glycation end products (AGEs). By improving endothelial function and reducing vascular stiffness, valsartan addresses underlying mechanisms of cardiovascular and metabolic diseases. Its dual action makes it an effective and multifaceted therapeutic agent.

References:

Mil, K.M., Gryciuk, M.E., Pawlukianiec, C., Żendzian-Piotrowska, M., Ładny, J.R., Zalewska, A., and Maciejczyk, M., 2021. Pleiotropic properties of valsartan: Do they result from the antiglycooxidant activity? Literature review and in vitro study. Oxidative Medicine and Cellular Longevity.

Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.

For more details consult with your doctor or healthcare professional.

FAQ
What is valsartan?
Valsartan is a selective angiotensin II type 1 (AT1) receptor blocker used to treat hypertension, chronic heart failure, and other cardiovascular conditions.
References:

Mil, K.M., Gryciuk, M.E., Pawlukianiec, C., Żendzian-Piotrowska, M., Ładny, J.R., Zalewska, A., and Maciejczyk, M., 2021. Pleiotropic properties of valsartan: Do they result from the antiglycooxidant activity? Literature review and in vitro study. Oxidative Medicine and Cellular Longevity.

How does valsartan work?
Valsartan blocks the AT1 receptor, preventing angiotensin II from causing blood vessel constriction, thereby lowering blood pressure and reducing cardiac strain.
References:

Mil, K.M., Gryciuk, M.E., Pawlukianiec, C., Żendzian-Piotrowska, M., Ładny, J.R., Zalewska, A., and Maciejczyk, M., 2021. Pleiotropic properties of valsartan: Do they result from the antiglycooxidant activity? Literature review and in vitro study. Oxidative Medicine and Cellular Longevity.

What are the additional benefits of valsartan?
Beyond blood pressure control, valsartan exhibits potential antioxidant and antiglycation properties, reducing oxidative stress and protein glycation associated with cardiovascular diseases.
References:

Mil, K.M., Gryciuk, M.E., Pawlukianiec, C., Żendzian-Piotrowska, M., Ładny, J.R., Zalewska, A., and Maciejczyk, M., 2021. Pleiotropic properties of valsartan: Do they result from the antiglycooxidant activity? Literature review and in vitro study. Oxidative Medicine and Cellular Longevity.