Liraglutide offers a novel approach for managing hind-limb ischemia, a severe vascular complication of diabetes. In experimental models, liraglutide significantly improved blood flow reperfusion and enhanced capillary density in ischemic tissues. These effects were driven by its ability to activate endothelial nitric oxide synthase (eNOS) and ERK1/2 signaling pathways, improving endothelial cell migration and proliferation. In vitro studies with human umbilical vein endothelial cells demonstrated liraglutide's capacity to overcome hyperglycemia-related vascular dysfunction. Its GLP-1 receptor-mediated actions underline its potential for stimulating angiogenesis, providing a promising treatment for peripheral artery disease and ischemia.
Zhu, Y., Li, Y., Ma, Y., Zhang, X., Du, X., Gao, J., Ding, N.H., Wang, L., Chen, N., Luo, M., Wu, J., & Li, R. (2023) 'Liraglutide Accelerates Ischemia‐Induced Angiogenesis in a Murine Diabetic Model', Journal of the American Heart Association.
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Zhu, Y., Li, Y., Ma, Y., Zhang, X., Du, X., Gao, J., Ding, N.H., Wang, L., Chen, N., Luo, M., Wu, J., & Li, R. (2023) 'Liraglutide Accelerates Ischemia‐Induced Angiogenesis in a Murine Diabetic Model', Journal of the American Heart Association.
Zhu, Y., Li, Y., Ma, Y., Zhang, X., Du, X., Gao, J., Ding, N.H., Wang, L., Chen, N., Luo, M., Wu, J., & Li, R. (2023) 'Liraglutide Accelerates Ischemia‐Induced Angiogenesis in a Murine Diabetic Model', Journal of the American Heart Association.
Zhu, Y., Li, Y., Ma, Y., Zhang, X., Du, X., Gao, J., Ding, N.H., Wang, L., Chen, N., Luo, M., Wu, J., & Li, R. (2023) 'Liraglutide Accelerates Ischemia‐Induced Angiogenesis in a Murine Diabetic Model', Journal of the American Heart Association.
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