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Liraglutide

Liraglutide

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Victorizafei Pen
Keifei Pharma
Substance Overview and History

Liraglutide, a GLP-1 analogue, demonstrates significant therapeutic potential for treating hind-limb ischemia, especially in the context of diabetes. By mimicking glucagon-like peptide-1, liraglutide enhances angiogenesis, restoring blood flow and capillary density in ischemic tissues. In diabetic and non-diabetic mouse models, liraglutide improved endothelial cell proliferation, migration, and tube formation, essential processes for vascular repair. Mechanistically, these benefits are mediated through the activation of Akt/eNOS and ERK1/2 signaling pathways, which are crucial for endothelial function. In vitro studies confirmed liraglutide's ability to reverse hyperglycemia-induced endothelial dysfunction, highlighting its role in managing chronic ischemic conditions.

References:

Zhu, Y., Li, Y., Ma, Y., Zhang, X., Du, X., Gao, J., Ding, N.H., Wang, L., Chen, N., Luo, M., Wu, J., & Li, R. (2023) 'Liraglutide Accelerates Ischemia‐Induced Angiogenesis in a Murine Diabetic Model', Journal of the American Heart Association.

Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.

For more details consult with your doctor or healthcare professional.

FAQ
What is Liraglutide?
Liraglutide is a synthetic GLP-1 analogue used primarily to treat type 2 diabetes and obesity. It mimics the effects of glucagon-like peptide-1 to regulate blood sugar and promote vascular health.
References:

Zhu, Y., Li, Y., Ma, Y., Zhang, X., Du, X., Gao, J., Ding, N.H., Wang, L., Chen, N., Luo, M., Wu, J., & Li, R. (2023) 'Liraglutide Accelerates Ischemia‐Induced Angiogenesis in a Murine Diabetic Model', Journal of the American Heart Association.

How does Liraglutide help in hind-limb ischemia?
Liraglutide promotes blood flow reperfusion and capillary density by enhancing endothelial cell function and stimulating angiogenesis in ischemic tissues.
References:

Zhu, Y., Li, Y., Ma, Y., Zhang, X., Du, X., Gao, J., Ding, N.H., Wang, L., Chen, N., Luo, M., Wu, J., & Li, R. (2023) 'Liraglutide Accelerates Ischemia‐Induced Angiogenesis in a Murine Diabetic Model', Journal of the American Heart Association.

What mechanisms underlie Liraglutide’s effects on vascular health?
Its benefits are mediated through activation of the Akt/endothelial nitric oxide synthase (eNOS) and ERK1/2 signaling pathways, which support endothelial function and blood vessel repair.
References:

Zhu, Y., Li, Y., Ma, Y., Zhang, X., Du, X., Gao, J., Ding, N.H., Wang, L., Chen, N., Luo, M., Wu, J., & Li, R. (2023) 'Liraglutide Accelerates Ischemia‐Induced Angiogenesis in a Murine Diabetic Model', Journal of the American Heart Association.