Toremifene, developed in the 1980s, is a SERM targeting metastatic breast cancer in postmenopausal women. It binds to receptors in breast tissue, stopping tumor growth. Primarily available as toremifene citrate, clinical trials confirm its effectiveness is comparable to tamoxifen. Has also been researched for other cancers, including ovarian and endometrial carcinoma. Studies on animals show reduced tumor occurrence, particularly in mammary glands, with indications of lowered cardiovascular risks in human trials.
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (1996). Some Pharmaceutical Drugs. Lyon (FR): International Agency for Research on Cancer. (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
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IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (1996). Some Pharmaceutical Drugs. Lyon (FR): International Agency for Research on Cancer. (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (1996). Some Pharmaceutical Drugs. Lyon (FR): International Agency for Research on Cancer. (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (1996). Some Pharmaceutical Drugs. Lyon (FR): International Agency for Research on Cancer. (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.