Addressing penicillin allergies is vital for optimizing antibiotic therapy in conditions like acute rheumatic fever (ARF) and rheumatic heart disease (RHD). While Benzathine penicillin G (BPG) is the standard for preventing RHD, many patients are unnecessarily labeled as penicillin-allergic, limiting treatment options. Testing reveals that most reported allergies are inactive or non-immunologic, allowing safe delabeling through low-dose oral challenges or skin testing. Correctly identifying penicillin allergies reduces inappropriate labeling, broadens therapeutic choices, and improves antimicrobial stewardship.
Providencia, R., Aali, G., Zhu, F., Leas, B.F., Orrell, R., Ahmad, M., Bray, J.J.H., Pelone, F., Nass, P., Marijon, E., Cassandra, M., Celermajer, D.S. and Shokraneh, F., 2024. Penicillin allergy testing and delabeling for patients who are prescribed penicillin: A systematic review for a World Health Organization guideline. Clinical Reviews in Allergy & Immunology.
Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.
For detailed information about Pen-os 1000 by Sandoz, consult with your doctor or healthcare professional.
Providencia, R., Aali, G., Zhu, F., Leas, B.F., Orrell, R., Ahmad, M., Bray, J.J.H., Pelone, F., Nass, P., Marijon, E., Cassandra, M., Celermajer, D.S. and Shokraneh, F., 2024. Penicillin allergy testing and delabeling for patients who are prescribed penicillin: A systematic review for a World Health Organization guideline. Clinical Reviews in Allergy & Immunology.
Providencia, R., Aali, G., Zhu, F., Leas, B.F., Orrell, R., Ahmad, M., Bray, J.J.H., Pelone, F., Nass, P., Marijon, E., Cassandra, M., Celermajer, D.S. and Shokraneh, F., 2024. Penicillin allergy testing and delabeling for patients who are prescribed penicillin: A systematic review for a World Health Organization guideline. Clinical Reviews in Allergy & Immunology.
Providencia, R., Aali, G., Zhu, F., Leas, B.F., Orrell, R., Ahmad, M., Bray, J.J.H., Pelone, F., Nass, P., Marijon, E., Cassandra, M., Celermajer, D.S. and Shokraneh, F., 2024. Penicillin allergy testing and delabeling for patients who are prescribed penicillin: A systematic review for a World Health Organization guideline. Clinical Reviews in Allergy & Immunology.