Myostatin plays a critical role in muscle regulation, acting as a suppressor of muscle growth by binding to ActRIIB receptors and activating SMAD pathways. This process reduces muscle cell proliferation and promotes degradation, particularly through interactions with the Akt/mTOR and FoxO1 pathways. Its levels are influenced by various factors, including TNF-α, IGF-1, and exercise, while being self-regulated via feedback loops. As a potential biomarker for sarcopenia and cachexia, myostatin faces challenges in assay specificity and clinical application, necessitating further research to validate its diagnostic and therapeutic relevance.
Baczek, J., Silkiewicz, M., & Wojszel, Z.B., 2020. Myostatin as a Biomarker of Muscle Wasting and Other Pathologies—State of the Art and Knowledge Gaps. Nutrients.
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For detailed information about MYO by Beligas Pharmaceuticals, consult with your doctor or healthcare professional.
Baczek, J., Silkiewicz, M., & Wojszel, Z.B., 2020. Myostatin as a Biomarker of Muscle Wasting and Other Pathologies—State of the Art and Knowledge Gaps. Nutrients.
Baczek, J., Silkiewicz, M., & Wojszel, Z.B., 2020. Myostatin as a Biomarker of Muscle Wasting and Other Pathologies—State of the Art and Knowledge Gaps. Nutrients.
Baczek, J., Silkiewicz, M., & Wojszel, Z.B., 2020. Myostatin as a Biomarker of Muscle Wasting and Other Pathologies—State of the Art and Knowledge Gaps. Nutrients.
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